A Comparative Study of Intramuscular 17 α-Hydroxyprogesterone Caproate and Oral Nifedipine in Management of Preterm Labor Pain

Dr. Shachi Panchariya, Dr. Seema Mehta, Dr. Manu Agrawal

Abstract: The aim of study was to compare efficacy and safety of intramuscular17 α hydroxy progesterone caproate and oral nifedipine in management of preterm labor. Study was conducted in 340 women divided in two groups after randomization. In group A (170 cases) single dose of injection 17 α hydroxyprogesteronecaproate (500mg) was given and in group B (170 cases) tablet oral nifedipine (30mg stat followed by 10 mg 8 hourly till 3 doses) was given. We conclude that both drugs have similar tocolytic effect, there was no statistically significant difference (p>0.005) in efficacy of these two drugs. But the prolongation of pregnancy was significantly longer (p<0.005) with 17OHPC and NICU stay was shorter (p <0.005) with 17OHPC.

Keywords: 17 α hydroxy progesterone caproate, 17OHPC), Nifedipine, Preterm labor, PROM, premature rupture of memberane