Modernize Devising Method of Ethosomes

Pankaj Yadav, Pallavi Tiwari

Abstract: Ethosomes are noninvasive drug delivery system that enables release of drug to deep skin layers or systemic circulation. Ethosomes are the ethanolic phospholipid vesicles which are used mainly for transdermal delivery of drugs. Over the year it has showed promising result in comparison to oral drug delivery system as it eliminates gastrointestinal interferences and first pass metabolism of the drug. Ethosomes have higher penetration rate through the skin as compared to liposomes hence these can be used widely in place of liposomes. Ethosomes, noninvasive delivery carriers that enable drugs to reach deep into the skin layers or the systemic circulation made up of phospholipids, high concentration of ethanol and water. This review article summarizes structure, advantages, disadvantages, composition and mechanism of drug penetration method of preparation, evaluation and applications of ethosomes.

Keywords: Transdermal Skin, Phospolipid, ethanol, Ethosomes