A Study of 100 Cases of Clinical Profile of Thalassemia Major Patients and Special Emphasis on Iron Chelation and Diastolic Dysfunction

Dr. Kalpesh J Chaudhary, Dr. Meghavi S Bhapal

Abstract: The present study consisted of 100 patients of thalassemia major who were in regular follow up in thalassemia ward at PDU Civil Hospital, Rajkot during the period of Sept 2019 to Oct 2020.They were evaluated clinically and laboratory investigated and ultrasound of abdomen & echocardiogram was done. Among them various clinical presentation like poor growth, fatigue, abdominal distention, jaundice, fracture, pedal edema, breathlessness were noted due to chronic hemolysis, extramedullary ineffective erythropoiesis, marrow expansion, platelet dysfunction, iron deposition in various organs & glands due to blood transfusion, in which cardiac complications are the major cause of morbidity and mortality among them.

Keywords: thalassemia, iron chelation, diastolic dysfunction

How to Cite?: Dr. Kalpesh J Chaudhary, Dr. Meghavi S Bhapal, "A Study of 100 Cases of Clinical Profile of Thalassemia Major Patients and Special Emphasis on Iron Chelation and Diastolic Dysfunction", Volume 10 Issue 6, June 2021, International Journal of Science and Research (IJSR), Pages: 1228-1230, https://www.ijsr.net/getabstract.php?paperid=SR21619180556, DOI: https://dx.doi.org/10.21275/SR21619180556