Disseminated Superficial Porokeratosis Associated with Gastro Intestinal Malignancy

Dr. Akshaya R C | Dr. Thillaikkarasi ^[2] | Dr. Narasimhalu C R V | Dr. Sonti Sulochana

Abstract: Porokeratosis is an uncommon keratinization disorder characterized by papules or plaque and elevated borders with distinct histological feature of cornoid lamella. Disseminated superficial porokeratosis is one of the variant of porokeratosis, which may be rarely associated with immune suppressive conditions and hematological malignancybut disseminated superficial porokeratosis in association with internal malignancy is uncommon.Herein we report a rare case of superficial disseminatedporokeratosissince childhood associated with gastrointestinal malignancy. A 46 year old female was referred to dermatology OPD with complaints of multiple dark raised lesions over the face, truck, back, upper limband lower limb since childhood. For the past 10 months the lesions started to worse by increasing size varying from 0.5 to 12cm and morphology with raised annular margin and central atrophy and it was associated with weight loss, decreased appetite and fatigue. Relevant investigations were done including histopathological examination of the colon and cutaneous lesion which confirmed the diagnosis of adenocarcinoma of colon and disseminated superficial porokeratosis respectively. This case is presented for its interesting features, that includes, the involvement of the cutaneous lesion on the u-v exposed areas as well as and the non-exposed areas, its association of adenocarcinoma of colon and the presence of family history of cutaneous lesion in her mother.

Keywords: Disseminatedsuperficialporokeratosis, cornoid lamella, gastrointestinal malignancy

Edition: Volume 10 Issue 6, June 2021,

Pages: 1034 - 1036