Cytokine Storm in COVID-19

Dr. Arup Halder

Abstract: COVID-19 pandemic has resulted a reincarnation of the term Cytokine storm The term is mostly used with another term called Sepsis. But the current pandemic has taught us of a cytokine storm much different from sepsis. Though the term sepsis is often used as a broad syndrome, it should be split into smaller and more homogeneous biological groups. Similarly, this theory is applicable for cytokine storm. The present article is a search for the cause of cytokine storm in COVID-19, the analysis of different pathways leading to cytokine storm and finding those candidates at risk of cytokine storm.

Keywords: COVID-19, Cytokine storm, Sepsis, Hemophagocytic Lymphohistiocytosis, HLH, Macrophage Activation Syndrome, MAS