Ecofriendly Application of Mixed Hydrotropy for Titrimetric Analysis of Ibuprofen Tablets

R. K. Maheshwari, Sumit Pathak, Prateek Sahu

Abstract: In the present study, mixed hydrotropy blend (MHB) containing 15% sodium salicylate, 5%w/v niacinamide, 5%w/v sodium acetate and 5%w/v sodium citrate have been employed to solubilize a poorly watersoluble drug, ibuprofen for its titrimetric analysis in tablets. Results of analysis by proposed methods were comparable with those of standard Indian pharmacopeial method. Results of analysis have been validated statistically. The proposed method is quicker than pharmacopeial method with its novelty, simplicity, accuracy and reproducibility.

Keywords: Mixed hydrotropy, ibuprofen, sodium salicylate, niacinamide, sodium acetate, sodium citrate, titrimetry