An Efficient Synthesis for Novel 2, 3-Disubstituted -4-Thiazolidones and Antimicrobial Evaluation

Kishor Huge, Vasant Gurav

Abstract: Novel 2-Methyl (2?-hydroxy-3?/5?-chloro-5?/3?-chloromethyl phenyl)- 3- ( 3?/4?-sustitutedphenyl)-4-thiazolidones are synthesized from 2-Hydroxy-3/5-chloro-5/3-chloromethyl acetophenone in good yield with purity. The structure of these compounds are confirmed by IR, 1H NMR and Mass spectra of a representative member from the series. These novel derivatives are then screened for antibacterial and antifungal activities against S. aureus, E. coli, X. citri, E. carotovora, C. albicans, T. rubrum, A. solani and H. turcicum.

Keywords: 2-Hydroxy-3/5-chloro-5/3-chloromethyl acetophenone, 2, 3-Disubstituted-4-thiazolidones, Antibacterial, Antifungal