Antibiotic-Resistant Neisseria gonorrhoeae: A Growing Threat of Multidrug Resistance

Ni Gusti Putu Raka Ariani | Paulus Mario Christopher ^[3] | Alfred Setyono

Abstract: The high incidence of Neisseria gonorrhoeae (N. gonorrhoeae) infection and resistance to antimicrobial treatment is a serious problem global matter. Lots of therapeutic options that have been used before are unable to deal with resistance. This resistance could be due to the development of microbial resistance to first-line treatment and has now demonstrated its ability to develop resistance to broad-spectrum cephalosporins, ceftriaxone, the last remaining option for first-line empiric treatment of gonorrhoea. Coordination to raise awareness for the use of new drug methods is important in persistent infectious reactions to gonorrhoea, which can cause reactions of pelvic inflammatory disease, infertility, and chronic pelvic pain in women; and epididymitis in men. The presence of gonorrhoea can also increase the risk of HIV acquisition and transmission. In this review article, we cover the evolution, origin, and spread of antimicrobial resistance and determinants of resistance (with a focus on broad-spectrum cephalosporins) in N. gonorrhoeae, detailing the current situation regarding broad-spectrum cephalosporin-verified treatment failure and future treatment options, and highlighting action are essential to meet the huge public health challenges that arise with the possibility of developing untreated gonorrhoea. One of the causes of the high rate of resistance can be the asymptomatic nature of gonorrhoea and its high virulence. Several methods can be used by the main lines of health in dealing with this case. The importance of being aware of the importance of screening and culture is very important. Counselling the affected partner can be the key to prevention.

Keywords: Neisseria gonorrhoeae, gonococcal, antimicrobial resistance, antimicrobial resistance

Edition: Volume 10 Issue 3, March 2021,

Pages: 925 - 929