Methicillin Resistant S. aureus (MRSA) Bacteremia: A Case Series and the Clinical Implications of Vancomycin MIC Creep

Gohel Swati Y, Praveen B, Thirunarayanan M A, Ramasubramanian V, Senthur Nambi P, Gopalakrishnan R

Abstract: Purpose: Methicillin resistant S. aureus (MRSA) bacteremia carries high morbidity and mortality. Very few studies from India have looked into the clinical features and outcome of MRSA bacteremia, at the same time some studies have noticed significant vancomycin MIC creep amongst MRSA isolates. Materials and Methods: It is a retrospective observational study conducted at a tertiary care centre over a period of five years, describing clinical characteristics and outcome of patients with MRSA bacteremia and attempted to analyse clinical implications of vancomycin MIC creep in MRSA bacteremia. Results: A total of 60 cases of MRSA bacteremia were studied. Prior antibiotic exposure (63.3%), recent hospitalisation (61.7%) and diabetes mellitus (40%) were the commonest potential risk factors. Fifteen percent of the study population had persistent bacteremia. There was no statistically significant difference in outcome between vancomycin and teicoplanin as empirical antibiotics. Our study demonstrated an increase in percentage of isolates with MIC ? 1 from 2011 to 2015. On an attempt to analyse clinical implication of this creep we found no statistically significant difference between high (MIC ? 1) and low (MIC

Keywords: MRSA, bacteremia, Vancomycin, MIC creep, Staphylococcus aureus

How to Cite?: Gohel Swati Y, Praveen B, Thirunarayanan M A, Ramasubramanian V, Senthur Nambi P, Gopalakrishnan R, "Methicillin Resistant S. aureus (MRSA) Bacteremia: A Case Series and the Clinical Implications of Vancomycin MIC Creep", Volume 11 Issue 1, January 2022, International Journal of Science and Research (IJSR), Pages: 31-36, https://www.ijsr.net/getabstract.php?paperid=SR211229054238, DOI: https://dx.doi.org/10.21275/SR211229054238

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