Downloads: 17 | Views: 55
Review Papers | Biological Sciences | India | Volume 10 Issue 12, December 2021
Overview of ACE-2 Receptor, Its Structure and Polymorphism and its Susceptibility to SARS-Cov-2, Influences of COVID-19 on Multi-Organs Cardiovascular Comorbidities, and COVID-19 Disease Outcome
Srinjoy Chattopadhyay | Vanshika Saini
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects human cells via binding a ?spike? protein on its surface to angiotensin-converting enzyme 2 (ACE2) within the host. ACE2 is crucial for maintaining tissue homeostasis and negatively regulates the renin-angiotensin-aldosterone system (RAAS) in humans. We employed our basic understanding of bioinformatics to give an overview of ACE-2 receptor, its structure and polymorphism and its susceptibility to SARS-Cov-2, influences of COVID-19 on multi-organs cardiovascular comorbidities, and COVID-19 disease outcome. This study may help in the significant understanding of the ongoing pandemic due to SARS-CoV-2 infection.
Keywords: ACE-2 receptor, SARS Cov-2, Spike glycoprotein, Receptor binding domain, dimers, transmembrane helix, virions, Collectrin like domain, polymorphism, RAAS, disintegrin, ARDS, TYK2 gene
Edition: Volume 10 Issue 12, December 2021,
Pages: 33 - 41
Similar Articles with Keyword 'polymorphism'
Downloads: 124
Research Paper, Biological Sciences, Morocco, Volume 6 Issue 8, August 2017
Pages: 998 - 1002TNF-? Receptor 1 Promoter Gene Polymorphisms and Susceptibility to Gastric Cancer Related to H. Pylori Infection in Moroccan Population
Ghizlane Bounder [2] | Amel Essadik | Hassan Jouhadi | Saloua Nadifiyine [2] | Hasna Boura [2] | Mohamed R. Jouimyi [2] | Anas Kettani | Halima Lebrazi | Fatima Maachi [2]
Downloads: 124
Research Paper, Biological Sciences, India, Volume 8 Issue 3, March 2019
Pages: 673 - 679Variation of Wild Cymbopogon martinii (Roxb.) in Different Ecotypes using Molecular Markers
Vijayalakshmi T. N. | Prof. Thara Saraswathi K. J.