International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064

Downloads: 17 | Views: 55

Review Papers | Biological Sciences | India | Volume 10 Issue 12, December 2021

Overview of ACE-2 Receptor, Its Structure and Polymorphism and its Susceptibility to SARS-Cov-2, Influences of COVID-19 on Multi-Organs Cardiovascular Comorbidities, and COVID-19 Disease Outcome

Srinjoy Chattopadhyay | Vanshika Saini

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects human cells via binding a ?spike? protein on its surface to angiotensin-converting enzyme 2 (ACE2) within the host. ACE2 is crucial for maintaining tissue homeostasis and negatively regulates the renin-angiotensin-aldosterone system (RAAS) in humans. We employed our basic understanding of bioinformatics to give an overview of ACE-2 receptor, its structure and polymorphism and its susceptibility to SARS-Cov-2, influences of COVID-19 on multi-organs cardiovascular comorbidities, and COVID-19 disease outcome. This study may help in the significant understanding of the ongoing pandemic due to SARS-CoV-2 infection.

Keywords: ACE-2 receptor, SARS Cov-2, Spike glycoprotein, Receptor binding domain, dimers, transmembrane helix, virions, Collectrin like domain, polymorphism, RAAS, disintegrin, ARDS, TYK2 gene

Edition: Volume 10 Issue 12, December 2021,

Pages: 33 - 41

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