International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064

Downloads: 1 | Views: 148

Research Paper | Chemistry | India | Volume 10 Issue 2, February 2021 | Rating: 4.2 / 10

Synthesis of 1-Acetyl-5-Substitutedaryl-3-[5?-(5??-Methoxy-3?-Indomethyl)-2?-Amino-1?, 3?, 4?-Thiadiazol-2?-N-Yl]-2-Pyrazoline Derivatives as Potent Anti-Inflammatory Agent

Anil Kumar [141]

Abstract: When 5-(5?-methoxy-3?-indomethyl)--1?, 3?, 4?-thiadiazol-2?-amino substituted chalcones (5a-5e) undergo cyclisation in presence of 99% hydrazine hydrate and few drops of glacial acetic acid and refluxed for 12 hours, a novel series of 1-acetyl-5-substitutedaryl-3-[5?-(5??-methoxy-3?-indomethyl)-2?-amino-1?, 3?, 4?-thiadiazol-2?-N-yl]-2-pyrazoline can be synthesised. These compounds were characterised by IR, NMR spectroscopy and screened for their promising anti-inflammatory activity.

Keywords: Thiadiazol, Indole, Chalcones, Pyrazoline, anti anti-inflammatory activity

Edition: Volume 10 Issue 2, February 2021,

Pages: 1692 - 1697

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