Downloads: 1 | Views: 118
Research Paper | Chemistry | India | Volume 10 Issue 2, February 2021
Synthesis of 1-Acetyl-5-Substitutedaryl-3-[5?-(5??-Methoxy-3?-Indomethyl)-2?-Amino-1?, 3?, 4?-Thiadiazol-2?-N-Yl]-2-Pyrazoline Derivatives as Potent Anti-Inflammatory Agent
Abstract: When 5-(5?-methoxy-3?-indomethyl)--1?, 3?, 4?-thiadiazol-2?-amino substituted chalcones (5a-5e) undergo cyclisation in presence of 99% hydrazine hydrate and few drops of glacial acetic acid and refluxed for 12 hours, a novel series of 1-acetyl-5-substitutedaryl-3-[5?-(5??-methoxy-3?-indomethyl)-2?-amino-1?, 3?, 4?-thiadiazol-2?-N-yl]-2-pyrazoline can be synthesised. These compounds were characterised by IR, NMR spectroscopy and screened for their promising anti-inflammatory activity.
Keywords: Thiadiazol, Indole, Chalcones, Pyrazoline, anti anti-inflammatory activity
Edition: Volume 10 Issue 2, February 2021,
Pages: 1692 - 1697