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Research Paper | Chemistry | Volume 10 Issue 2, February 2021 | Pages: 1692 - 1697 | India
Synthesis of 1-Acetyl-5-Substitutedaryl-3-[5?-(5??-Methoxy-3?-Indomethyl)-2?-Amino-1?, 3?, 4?-Thiadiazol-2?-N-Yl]-2-Pyrazoline Derivatives as Potent Anti-Inflammatory Agent
Abstract: When 5-(5?-methoxy-3?-indomethyl)--1?, 3?, 4?-thiadiazol-2?-amino substituted chalcones (5a-5e) undergo cyclisation in presence of 99% hydrazine hydrate and few drops of glacial acetic acid and refluxed for 12 hours, a novel series of 1-acetyl-5-substitutedaryl-3-[5?-(5??-methoxy-3?-indomethyl)-2?-amino-1?, 3?, 4?-thiadiazol-2?-N-yl]-2-pyrazoline can be synthesised. These compounds were characterised by IR, NMR spectroscopy and screened for their promising anti-inflammatory activity.
Keywords: Thiadiazol, Indole, Chalcones, Pyrazoline, anti anti-inflammatory activity
How to Cite?: Anil Kumar, "Synthesis of 1-Acetyl-5-Substitutedaryl-3-[5?-(5??-Methoxy-3?-Indomethyl)-2?-Amino-1?, 3?, 4?-Thiadiazol-2?-N-Yl]-2-Pyrazoline Derivatives as Potent Anti-Inflammatory Agent", Volume 10 Issue 2, February 2021, International Journal of Science and Research (IJSR), Pages: 1692-1697, https://www.ijsr.net/getabstract.php?paperid=SR21111172532, DOI: https://dx.doi.org/10.21275/SR21111172532