An Out of the Ordinary Case Report of Ticagrelor Furthering Rhabdomyolysis Induced by Atorvastatin

Dr Nishant Agrawal, Dr Shivakumar Iyer, Dr Jignesh Shah, Dr Prashant Jedge

Abstract: Rhabdomyolysis is an evidential aftermath of statin therapy and contemporaneous use of medications like ticagrelor that inhibit cytochrome P450-3A4 enzyme increases it’s risk by causing muscle necrosis and release of myoglobin into circulation. We hereby report a case of a 63 year old male patient who was commenced on ticagrelor, post transluminal coronary angioplasty on a background of atorvastatin therapy resulting in rhabdomyolysis with acute kidney injury and hyperkalemia. This case highlights the need for awareness of drug interactions with atorvastatin and lastly, importance of early diagnosis and management of rhabdomyolysis so as to prevent the development of further complications.

Keywords: Rhabdomyolysis, atorvastatin, ticagrelor