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Case Studies | Medical Science | India | Volume 11 Issue 11, November 2022
The Utility of Bone Marrow Biopsy in Underlying Case of Hodgkin Lymphoma - A Case Report in Young Male
Dr. Jasmeenkaur | Dr. Anita Tahlan
Abstract: The frequency of bone marrow infiltration by Hodgkin lymphoma is low and varies from 3 to 18%. Clinically it represents stage IV disease. HL is categorisd into histological types, along with association of Epstein-Barr virus and its immunophenotype, BM infiltration in HL differs between populations. A 16 years old male presented with right cervical lymphadenopathy level V since 1 year 6 months. Fine needle aspiration and histopathology shows features of nodular sclerosis-hodgkin lymphoma. Most of the cases of Hodgkin lymphoma are diagnosed mainly by histomorphology. Further, for staging marrow bone marrow aspiration and biopsy was done. They also showed infiltration by lymphoma cells. To confirm Hodgkin lymphoma, immunohistochemical stains were done. Bone marrow infiltration by Hodgkin lymphoma is rare only 13% cases showed bone marrow infiltration in literature. This case report highlights the clinicopathological features and the histomorphology of bone marrow infiltration by Hodgkin Lymphoma-Nodular Sclerosis. Case report: A 16 years old male presented with painless right cervical lymphadenopathy (Level V), loss of weight and appetite for 1 year and 6 months. Fine needle aspiration showed features of classical hodgkin lymphoma and histopathology showed features of classical Hodgkin's lymphoma-nodular sclerosis. Further, staging marrow was done. Bone marrow aspiration and biopsy showed infiltration by Reed-Sternberg cells. To confirm Hodgkin lymphoma, immunohistochemical stains CD 45 and CD 15 were done. Conclusions: This case report highlights the clinicopathological features and the histomorphology of bone marrow infiltration by classical Hodgkin's Lymphoma-Nodular Sclerosis. As the role of bone marrow aspirate is minimal in the staging of Hodgkin lymphoma, bone marrow biopsy should always be done.
Keywords: Hodgkin's lymphoma, nodular sclerosis, bone marrow biopsy
Edition: Volume 11 Issue 11, November 2022,
Pages: 390 - 392