Curative Effect of L-Arginine on Neurotoxicity Mice Model

Sherin Ramadan Hamad

Abstract: Purpose: Our study aimed to evaluate the therapeutic effect of L-Arginine onneuron damage induced byhigh dose of monosodium glutamate in brain of Swiss albino mice using histopathological and histochemical examinations. Design/ Methodology/ Approach: Twenty animals were divided into four groups: control group; neurotoxicity model group, arginine treated group and neurotoxicity model- arginine treated group. The experimental period was ten successive days. Findings: Administration of L-Arginine in neurotoxicity model animals resulted in marked ameliorations of cerebellum damage observed in neurotoxicity model group as evidenced by reappearance of normal histological structure and Nissl's granules in Purkinje cells and restore lost cells of granular layers. In conclusions, the administration of L-Arginine could suppress the neurotoxicity induced by high dose of monosodium glutamate. We suggest that L-Arginine may be useful in combating neuron damage.

Keywords: Neurotoxicity, L-Arginine, Histopathologicalstudy, Nissl's granules, brain, Mice