Downloads: 166
Research Paper | Chemistry | Volume 9 Issue 6, June 2020 | Pages: 84 - 87 | India
Synthesis, Structure Elucidation and Assessment of Microbial Activity of Schiff Bases derived from Condensation of 2-(2-oxo-2H-1-benzopyran-3-carbonyl) hydrazine-1-carboxamide with Aldehyde Derivatives
Abstract: Some pharmacologically active novel Schiff Bases derived by condensation of 2- (2-oxo-2H-1-benzopyran-3-carbonyl) hydrazine-1-carboxamide with various aldehyde derivatives by using catalytically amount of glacial acetic acid. Such compounds were elucidated by different physico-chemical techniques like, melting point, IR, 13CNMR, mass, elemental analysis. The novel Schiff bases bearing coumarin moiety have been screened for their anti-microbial activity by disc diffusion method. The Schiff base derivative of N- [ (2-hydroxyphenyl) methylidene]-2- (2-oxo-2H-1-benzopyran-3-carbonyl) hydrazine-1-carboxamide (IIb) and N- [ (4-nitrophenyl) methylidene]-2- (2-oxo-2H-1-benzopyran-3-carbonyl) hydrazine-1-carboxamide (IIc) show more potent anti-microbial activities compared with its other derivatives.
Keywords: Condensation, Structure elucidation, Anti-microbial
How to Cite?: Alka Pradhan, Anil Kumar Koshal, "Synthesis, Structure Elucidation and Assessment of Microbial Activity of Schiff Bases derived from Condensation of 2-(2-oxo-2H-1-benzopyran-3-carbonyl) hydrazine-1-carboxamide with Aldehyde Derivatives", Volume 9 Issue 6, June 2020, International Journal of Science and Research (IJSR), Pages: 84-87, https://www.ijsr.net/getabstract.php?paperid=SR20529170048, DOI: https://dx.doi.org/10.21275/SR20529170048