Synthesis and Characterization of Benzylidene Derivatives Using Various Solvents, Catalysts and Green Chemistry Methods

Dr. Atiyatulhai, Dr. Maryam Fatima, Dr. Aishaateeq

Abstract: The work presented in thesis describes the synthesis of benzylidene as potential anti-bacterial agents. In the past few decades, intensive research experienced a significant development consequently leading to the availability of various anti-bacterial drugs in the market. However, these drugs suffer from some limitations and their use is limited due to their less bioavailability, immunogenicity and low stability. These shortcomings necessitated the development of new antibiotic drugs. The biological activity of these drugs is generally exerted by small regions in their zone of inhibition. In this context, we have designed and synthesized benzylidene by green chemistry techniques with good yields and created a data of advantages between the synthesis from regular techniques. The structures of all the compounds were unambiguously established on the basis of spectral data (IR spectra). In this context, we have screened the synthesized benzylidines for antibacterial activity and found that the molecules are comparatively active against several gram positive and gram negative bacteria which lead good source of developing benzylidenes as anti bacterial agents.

Keywords: Benzylidenes, antibacterial, immunogenicity, IR spectra, antibiotics