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Research Paper | Anaesthesiology | India | Volume 9 Issue 3, March 2020
Attenuation of Haemodynamic Responses to Laryngoscopy and Endotracheal Intubation using Esmolol and Lignocaine - A Comparative Study
Dr. M. Venkat Rama Rao | Dr. T. Surya Sree 
Abstract: AIM: To compare the efficacy of Esmolol Hcl & Lignocaine Hcl in attenuation of hemodynamic response to Laryngoscopy and Endotracheal Intubation. MATERIALS & METHODOLOGY: A randomized, prospective, double-blind study in which 60 patients of ASA grade I or II aged between 20–60 years was conducted. LignocaineHcl 1 mg/kg and Esmolol Hcl 0.5 mg/kg were compared in attenuating the haemodynamic response to laryngoscopy and tracheal intubation in elective surgery under general anaesthesia. Patients were divided into two groups Group L (Lignocaine): patients receive injection Lignocaine, 1 mg/kg IV bolus diluted to 10 ml with 0.9 % saline. Group E (Esmolol): patients receives injection Esmolol 0.5 mg/kg IV bolus diluted to 10 ml with 0.9 % saline. All the selected patients are subjected to the same anaesthesia technique. HR, SBP, DBP and MAP were recorded before intubation, and then during intubation 0 minute, 1 min, 3 min, 5 min of intubation. RESULTS: Systolic, Diastolic & Mean Arterial Pressures increased significantly in lignocaine group whereas it was attenuated more effectively in Esmolol group (p<0.05). CONCLUSION: Esmolol is more effective than lignocaine in attenuating the haemodynamic response to laryngoscopy and tracheal intubation.
Keywords: Esmolol, Lignocaine, haemodynamic response, General anaesthesia
Edition: Volume 9 Issue 3, March 2020,
Pages: 1086 - 1088