International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 172 | Views: 225

Research Paper | Biotechnology | India | Volume 9 Issue 3, March 2020


Meta-Analysis: A Higher Quality of Evidence in Clinical Research Pyramid

Dr. Sonal Jain


Abstract: Meta-analysis is a statistical tool used to systematically and quantitatively estimate the pooled effect of earlierindividual research studies to obtain conclusions about that research subject. The outcomes from a meta-analysis are more precise estimate of the effect of treatment or risk factor for disease, than any individual study. One of the potential advantages of conducting meta-analysis is to obtain an accurate and quantitative review of a large, complex and generally controversial topic in literature. Meticulously conducted meta-analyses are potential tools in evidence-based medicine. The small clinical trials (small sample size) might have inconclusive results on individual basis however, while combining these trials met-analysis increases the statistical power and thus more precise estimate of effect size. Moreover, meta-analysis is also useful for exploring sources of publication bias and quantifying between-study heterogeneity.


Keywords: meta-analysis, systematic review, evidence-based medicine, effect size, forest plot, publication bias, heterogeneity


Edition: Volume 9 Issue 3, March 2020,


Pages: 340 - 349


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