Formulation and Evaluation of Aripiprazole-IR Tablets by Direct Compression Method

T. Lepakshi, A. Balakrishna, P. Sivakumar, M. Surendra, G. Sabjjath

Abstract: ARIPIPRAZOLE used as antipsychotic drug therapy in the form of immediate release tablet. this paper represents the disintegrants like starch, pre gelatinated starch, and corn starch which are used as suitable disintegrants for drug release by direct compression method. in this study we take 8 formulations in that used various disintegrants. From this study it concluded that formulation (F4) which contained corn starch as disintegrant showed good dissolution profile with innovator.

Keywords: ARIPIPRAZOLE, starch, pregelatinated starch, corn starch, direct compression method