Malignant Phyllodes Tumor with Heterologous Differentiation

Sarita Mittal, Swati Girdhar, Maneesh Bagai

Abstract: Phyllodes tumors are uncommon fibroepithelial neoplasms of breast. Heterologous sarcomatous differentiation of malignant phyllodes tumor (MPT) is a rare phenomenon as shown in the literature. Herein we report two cases of female in thirties were diagnosed with phyllodes tumor with heterologous differentiation. The rst patient had malignant phyllodes tumor with smooth muscle differentiation and the second patient had Phyllodes tumor with chondrosarcomatous differentiation. Proper diagnosis and subtyping of the sarcomatous component is essential for deciding the correct treatment modality and prognostication of the disease. However there is no clear cut treatment protocol is available because of paucity of data.

Keywords: Heterologous differentiation, malignant phyllodes tumor, sarcoma breast