Study of Novel Nanodevices for Cancer Biomarker Detection

Pantha Protim Sarker, Chayan Mondal

Abstract: A multi-dimension theoretical study of novel nanodevices for application in cancer biomarker detection is presented in this work. Nanoscale 1D bio FETs, microfluidic chips, and nanopore devices are covered here. Computer simulation of Si bio FETs has been carried out where selectivity of double-gate FET biosensors are investigated for a number of significant cancer biomarkers, namely, TOP2A, CK19, HER2, S100P, and EGFR. At first, individual selectivity of the biomarkers are analyzed in their respective biological test environments and then chi-square test along with Bayesian analysis is performed to study the possibility of parallel detection of these biomarkers in a common environment. Molecular dynamics has been used to simulate the bio-environment for nanopores. Finally, the paper presents COMSOL simulation of a practical microfluidic lab-on-a-chip (LOAC) and a device prototype development process via 3D printing technology.

Keywords: Nanoscale 1D bio FETs, Nanobiosensor, Silicon Nanopore, Cancer Biomarker, Microfluidic chips