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Research Paper | Biochemistry | India | Volume 9 Issue 11, November 2020 | Popularity: 6.7 / 10

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Anti Inflammatory Activity of Ferulic Acid against Carrageenan and Formalin Induced Paw Edema in Swiss Albino Mice

Saratchandran A. Divakaran, Anitha CT

Abstract: The anti-inflammatory activity of ferulic acid (FA) was evaluated using carrageenan and formalin-induced paw edema models in Swiss albino mice. The anti-inflammatory activity was found to be dose dependent in both paw edema model. Administration of the FA showed significant (p˂0.001) inhibition of paw edema, 28 % and 37.5 % on 6th hour at the doses of 100 and 200 mg/kg body weight respectively in Carrageenan induced paw edema model. Similar pattern of paw edema inhibition was seen in formalin-induced paw edema model. The maximum percentage inhibition in paw edema was 31.4 % and 46.87 % on 6 th day at the doses of 100 and 200 mg/kg, respectively. The results of present study demonstrate that FA possess significant anti-inflammatory potential.

Keywords: anti-inflammatory activity, paw edema, carrageenan, formalin

Edition: Volume 9 Issue 11, November 2020

Pages: 788 - 792