Correlation of Elevated Mast Cell Density with Microvessel Density in Various Grades of Oral Submucous Fibrosis

Dr Sabu Paul, Dr Pramod P Mathews

Abstract: Aim: To correlate the elevated mast cell density with the microvessel density in various grades of oral submucous fibrosis. Materials and Methods: H and E stained sections of oral submucous fibrosis (OSMF) were examined and microvessel density (MVD) quantified using an image analyzer. Mast cell density (MCD) calculated using a microscope fitted with a calibrated mechanical stage. Statistics: ANOVA was used to test the equality of means between MVD and MCD. Results: Mast cell density showed a consistent increase with Microvessel density in different grades of OSMF although the correlation was statistically insignificant. Discussion: Mast cells play a significant role in inducing angiogenesis in OSMF and modalities to control mast cell mediators would in turn improve the prognosis of OSMF patients.

Keywords: mast cell density, microvessel density, image analysis, oral submucous fibrosis

How to Cite?: Dr Sabu Paul, Dr Pramod P Mathews, "Correlation of Elevated Mast Cell Density with Microvessel Density in Various Grades of Oral Submucous Fibrosis", Volume 6 Issue 7, July 2017, International Journal of Science and Research (IJSR), Pages: 2275-2277, https://www.ijsr.net/getabstract.php?paperid=SR17716155656, DOI: https://dx.doi.org/10.21275/SR17716155656