Downloads: 1 | Views: 98 | Monthly Hits: ⮙1

Research Paper | Pathology | India | Volume 6 Issue 7, July 2017

Correlation of Elevated Mast Cell Density with Microvessel Density in Various Grades of Oral Submucous Fibrosis

Dr Sabu Paul ^[4] | Dr Pramod P Mathews ^[3]

Abstract: Aim: To correlate the elevated mast cell density with the microvessel density in various grades of oral submucous fibrosis. Materials and Methods: H and E stained sections of oral submucous fibrosis (OSMF) were examined and microvessel density (MVD) quantified using an image analyzer. Mast cell density (MCD) calculated using a microscope fitted with a calibrated mechanical stage. Statistics: ANOVA was used to test the equality of means between MVD and MCD. Results: Mast cell density showed a consistent increase with Microvessel density in different grades of OSMF although the correlation was statistically insignificant. Discussion: Mast cells play a significant role in inducing angiogenesis in OSMF and modalities to control mast cell mediators would in turn improve the prognosis of OSMF patients.

Keywords: mast cell density, microvessel density, image analysis, oral submucous fibrosis

Edition: Volume 6 Issue 7, July 2017,

Pages: 2275 - 2277