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Research Paper | Pathology | India | Volume 6 Issue 7, July 2017 | Popularity: 4.7 / 10
Correlation of Elevated Mast Cell Density with Microvessel Density in Various Grades of Oral Submucous Fibrosis
Dr Sabu Paul, Dr Pramod P Mathews
Abstract: Aim: To correlate the elevated mast cell density with the microvessel density in various grades of oral submucous fibrosis. Materials and Methods: H and E stained sections of oral submucous fibrosis (OSMF) were examined and microvessel density (MVD) quantified using an image analyzer. Mast cell density (MCD) calculated using a microscope fitted with a calibrated mechanical stage. Statistics: ANOVA was used to test the equality of means between MVD and MCD. Results: Mast cell density showed a consistent increase with Microvessel density in different grades of OSMF although the correlation was statistically insignificant. Discussion: Mast cells play a significant role in inducing angiogenesis in OSMF and modalities to control mast cell mediators would in turn improve the prognosis of OSMF patients.
Keywords: mast cell density, microvessel density, image analysis, oral submucous fibrosis
Edition: Volume 6 Issue 7, July 2017
Pages: 2275 - 2277
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