Exosomes as Liquid Biopsy: A Review

I G K N Arijana, I G N Sri Wiryawan, N M Linawati, I G N Mayun, I W Sugiritama, I G A Dewi Ratnayanti

Abstract: Exosomes are nano-sized vesicles that contain protein, DNAs, mRNAs, miRNAs and ncRNAs. Their diameter is ranging from 40-100 nm and can be found in various biological fluids such as plasma, saliva, urine etc. Exosomes gain attention due to their content especially miRNAs which can regulate another cells. This regulation is important in diseases such as cancers, immune disorders, neurodegenerative diseases and infections. The review will focus in exosomal miRNA as liquid biopsy in cancers due to their advantages over traditional tissue biopsy.

Keywords: exosomes, miRNAs, liquid biopsy, tissue biopsy