Burden of Lupus Nephritis among Patients Managed in Routine Clinical Practices in Europe

Siva Narayanan MS MHS

Abstract: Assessing the characteristics of patients with Lupus Nephritis (LN) in comparison to those without LN among patients with systemic lupus erythematosus (SLE) could help portray LN disease burden. A multi-center chart review of adult SLE patients was conducted among rheumatologists/internal medicine physicians in UK/France/Germany/Italy/Spain (EU5) to collect data on disease characteristics and treatment patterns.168 LN patients and 569 non-LN patients with SLE were analyzed. Among LN/Non-LN cohorts, % currently receiving care in in-patient setting was14.9/8.8, % hospitalized >=1 in the past-year was49.4/29.7. Clinical burden (patients experiencing a flare, low C3/C4, higher SELENA-SLEDAI scores) and humanistic burden (diminished ability to perform every-day tasks, interact fully with family and friends, or work/keep employment) was higher among LN cohorts. Factors influencing the observed burden, including the therapeutic strategies used in these geographies warrant further investigation to manage LN optimally.

Keywords: Lupus Nephritis, Burden, Flares, Hospitalizations, Europe

How to Cite?: Siva Narayanan MS MHS, "Burden of Lupus Nephritis among Patients Managed in Routine Clinical Practices in Europe", Volume 5 Issue 5, May 2016, International Journal of Science and Research (IJSR), Pages: 1364-1367, https://www.ijsr.net/getabstract.php?paperid=NOV163718, DOI: https://dx.doi.org/10.21275/NOV163718