Protective Effect of Andrographis paniculata against Thioacetamide Cytotoxicity in Liver and Kidney of Albino Rat

Patil R. N, Salunkhe A. J

Abstract: The present work has been designed to check hepatoprotective and renoprotective potency of aqueous extract of Andrographis paniculata. The whole plant extract of A. paniculata was used for treatment by using thioacetamide induced toxicity in liver and kidney of albino rat. Thioacetamide induces liver cirrhosis and nephrosclerosis. Thioacetamide induced toxicity in albino rat as manifested by the significant increase in total bilirubin, direct bilirubin, SGPT, SGOT and creatinine while significant decrease in liver protein and kidney protein. These results prove the potential hepatoprotective and renoprotective activity of A. paniculata extract.

Keywords: A paniculata, liver, and kidney