Haloperidol: A Novel Use in Ketamine Induced Postoperative Fulminant Psychosis

Shahla Haleem, Muazzam Hasan, Nida Fatima, Md Kashif Jamal

Abstract: We report a case of severe/fulminant psychosis in an intellectually disabled healthy teenage female operated for the fracture shaft of the femur after post polio residual para-paresis under spinal anaesthesia. For intra-operative sedation, injection ketamine was used in subanaesthetic doses following midazolam premedication. Postoperatively she developed severe psychosis for which injection diazepam and midazolam were unsuccessful to manage the psychological crisis. Finally, ketamine induced unmanageable fulminant psychosis was controlled by injection haloperidol.

Keywords: Ketamine, Haloperidol, Glutamate, Psychosis, Anaesthesia