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M.Tech / M.E / PhD Thesis | Biochemistry Science | Nigeria | Volume 5 Issue 1, January 2016

Effect of Leptadeniahastata ETHANOLIC Extract in Wistar Rats

Bakodo Pwainginomi Confidence | Nadro Margaret Samuel | Panuel Boniface

Abstract: Leptadenia hastata (Pers. ) Decne is edible non-domesticated vegetable and it is used in the treatment of diabetes, hypertension, skin diseases catarrh, prostate and rheumatism. This study was designed to investigate the effect of ethanol extract of Leptadenia hastata on wistar rats. Acute and chronic toxicity were conducted. The acute toxicity study of ethanol extract of Leptadenia hastata showed no toxicity when administered up to 5000mg/kg body weight orally. In the chronic toxicity study, different doses of the ethanol extract were administered to rats at 100 mg/kg body weight, 200 mg/kg body weight and 400 mg/kg body weight for 30 consecutive days. The levels of serum AST and ALT of treated animals significantly (p<0.05) decreased compared to the control group. The serum albumin of treated animals showed significant (p<0.05) increase compared to the control group. There was significant decrease in the serum levels of urea of the treated animals compared to the control, also significant increase (p<0.05) in PCV and Hb were observed in the treated animals compared to the control. The result therefore suggests that Leptadenia hastata could be safe for consumption orally even at chronic administration.

Keywords: Leptadenia hastata, acute toxicity, chronic toxicity, wistar rats and haematology

Edition: Volume 5 Issue 1, January 2016,

Pages: 609 - 612