A Novel Approach to the Synthesis of Some Naphthofuran Derivatives Bearing Polar Substituents for Studying their Antimicrobial Activity
Abstract: -Naphthol on reaction with N- (hydroxyalkyl) -arylamides/ imides (1) in ethanol containing catalytic amount of conc. HCl furnishes N- (2-hydroxy-naphthalen-1-yl-alkyl) -arylamides/ imides (2) which on treatment with benzoin in dioxan containing triethylamine (TEA) affords N- (2, 3- diphenyl-naphtho [2, 3-b] furan-9-yl-alkyl) - arylamides/ imides (3). Compounds 3 have been evaluated for their antimicrobial activity involving four bacterial and six fungal strains.
Keywords: Antimicrobial resistance, nitrofurazone, amidoalkylation
How to Cite?: Dr. Amar Singh Yadav, Kaman Singh, "A Novel Approach to the Synthesis of Some Naphthofuran Derivatives Bearing Polar Substituents for Studying their Antimicrobial Activity", Volume 5 Issue 1, January 2016, International Journal of Science and Research (IJSR), Pages: 606-608, https://www.ijsr.net/getabstract.php?paperid=NOV152767, DOI: https://dx.doi.org/10.21275/NOV152767