Effect of Methanol Root Extract of Senna occidentalis against Carbon Tetrachloride-Induced Hepatic Damage in Rats

Kwalle Joseph John, Bello M. I.

Abstract: Protective effect of methanol root extract of Senna occidentalis was investigated against carbon tetrachloride (CCl4) induced hepatic damage in white Wistar strain albino rats. Hepatic damage was induced by injecting a single intraperitoneal dose of 1.0 ml (50 % volume/volume) CCl4 in olive oil. Plant extract (100, 200 and 300 mg/kg body weight) was given for seven days. Hepatic damage was induced and the animals were scarified after 48 hours. The hepatoprotective effect of the extract was monitored by estimating the activities of the serum AST (Aspartate Aminotransferase), serum ALT (Alanine Amino Transferase), serum ALP (Alkaline Phosphatase), Total proteins, unconjugated bilirubin and conjugated bilirubin. This observation could be supported by some Phytochemicals detected in the methanol root extract. Results showed that methanol extract of Senna occidentalis possessed hepatoprotective activity by significantly (p

Keywords: Senna occidentalis, in-vitro antioxidant, hepatoprotective, Phytochemicals screening

How to Cite?: Kwalle Joseph John, Bello M. I., "Effect of Methanol Root Extract of Senna occidentalis against Carbon Tetrachloride-Induced Hepatic Damage in Rats", Volume 5 Issue 2, February 2016, International Journal of Science and Research (IJSR), Pages: 2036-2040, https://www.ijsr.net/getabstract.php?paperid=NOV152115, DOI: https://dx.doi.org/10.21275/NOV152115

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