Evaluation of Adenanthera pavonina Bark Extracts for Antioxidant Activity and Cytotoxicity against Cancer Cell Lines

Renilda Sophy A. J., Albin T. Fleming

Abstract: Plant materials were used for the treatment of malignant diseases for centuries. Various studies on plant extract which have a suitable history of use in folklore for the treatment of cancer had often resulted in the isolation of principles with anti-tumour activity. In the present study, the anti-proliferative effect of acetone and methanol bark extracts of Adenanthera pavonina on three cancer cell lines using sulforhodamine-B assay and their antioxidant activities using 1-diphenyl-2-picrylhydazyl radical and its reducing ability were investigated. NCI-H460, U251, and MCF7 cancer cell lines were used in this assay. The GI50 value of methanol extract showed a lowest value of 27g/mL against NCI-H460. The antioxidant and the reducing power assay showed a significant dose dependant activity. The study also suggests that antioxidant activity of these extracts might be one of the reasons for the anticancer potential of the extracts.

Keywords: Extracts, anti-tumor, cell lines, antioxidant, cytotoxicity