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Comparative Study | Medicine | Volume 15 Issue 7, July 2026 | Pages: 2012 - 2017 | India
Esophageal Motility Changes Following Endoscopic Variceal Band Ligation in Cirrhotic Patients with Esophageal Varices: A Prospective High-Resolution Manometry Study Using Chicago Classification v4.0
Abstract: Endoscopic variceal band ligation (EVBL) is the standard endoscopic treatment for esophageal varices in cirrhosis, but its effect on esophageal motility, when assessed using high-resolution manometry (HRM) and interpreted by the Chicago Classification version 4.0 (CCv4.0), remains poorly characterised. We aimed to evaluate esophageal motility changes before and after EVBL in cirrhotic patients with esophageal varices. In this prospective observational study conducted at a tertiary care centre in northern India, 26 consecutive cirrhotic patients with grade 2-3 esophageal varices scheduled for EVBL underwent HRM before the procedure and again 4-6 weeks afterward. Lower esophageal sphincter (LES) and upper esophageal sphincter (UES) pressures, integrated relaxation pressure (IRP), and esophageal body motility parameters were compared using paired t-tests or Wilcoxon signed-rank tests as appropriate. Categorical HRM diagnoses were compared using McNemar's test. Subgroup analysis was performed by Child-Pugh class, and correlation between the number of bands applied and change in IRP (ΔIRP) was assessed using Pearson and Spearman coefficients. Mean LES basal pressure rose from 30.13 ± 8.12 to 39.53 ± 9.53 mmHg (Δ +9.40 mmHg; p
Keywords: esophageal variceal band ligation, high-resolution manometry, Chicago Classification, esophagogastric junction outflow obstruction, liver cirrhosis, portal hypertension
How to Cite?: Awan Verma, Saurabh Singhal, Abhishek Yadav, "Esophageal Motility Changes Following Endoscopic Variceal Band Ligation in Cirrhotic Patients with Esophageal Varices: A Prospective High-Resolution Manometry Study Using Chicago Classification v4.0", Volume 15 Issue 7, July 2026, International Journal of Science and Research (IJSR), Pages: 2012-2017, https://www.ijsr.net/getabstract.php?paperid=MR26722123847, DOI: https://dx.doi.org/10.21275/MR26722123847