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Case Report | Obstetrics and Gynecology | Volume 15 Issue 6, June 2026 | Pages: 120 - 123 | India
Life-Saving Role of Factor VIII in Refractory Obstetric Hemorrhage Associated with Abruptio Placentae and HELLP Syndrome: A Case Report
Abstract: This case report describes a 27-year-old woman with previous cesarean delivery who presented with abruptio placentae, intrauterine fetal death, HELLP syndrome, severe anemia, and consumptive coagulopathy. Emergency laparotomy was performed because of maternal deterioration and transverse fetal lie. Persistent hemorrhage continued despite uterotonics, uterine artery ligation, compression sutures, massive transfusion, and intensive supportive care. Following administration of the coagulation Factor VIII was administered intravenously at a dose of 250 IU diluted in 10 ml NS, hemostasis improved substantially and bleeding was controlled. The patient recovered gradually and was discharged in stable condition. This case highlights the potential role of t coagulation factor VIII therapy as rescue treatment in carefully selected patients with refractory obstetric hemorrhage associated with severe placental abruption and HELLP syndrome.
Keywords: Abruptio placentae, HELLP syndrome, Disseminated intravascular coagulation, Obstetric hemorrhage, Postpartum hemorrhage, Coagulation factor therapy, Maternal morbidity
How to Cite?: Dr Swapnil Wasekar, Dr Shrinivas Gadappa, Dr Rupali Gaikwad, Dr Meghna Malu, "Life-Saving Role of Factor VIII in Refractory Obstetric Hemorrhage Associated with Abruptio Placentae and HELLP Syndrome: A Case Report", Volume 15 Issue 6, June 2026, International Journal of Science and Research (IJSR), Pages: 120-123, https://www.ijsr.net/getabstract.php?paperid=MR26602014633, DOI: https://dx.dx.doi.org/10.21275/MR26602014633