Sub Classification of Periampullary Carcinoma in Whipple?s Specimen Received Using Immunohistochemistry Markers Mucin1 (MUC1), Cytokeratin 20 (CK20) & Caudal Type Homeodomain Transcription Factor (CDX2) - A Tertiary Care Study
Abstract: Background: Periampullary carcinoma (PAC) is a rare malignancy arising near the ampulla of Vater. Accurate histological subtyping into intestinal (INT), pancreatobiliary (PB), and mixed types is crucial for prognosis and therapeutic guidance. Morphological classification often lacks consistency, making immunohistochemistry (IHC) a vital tool. Objective: To subclassify PACs from Whipple?s specimens using IHC markers-MUC1, CK20, and CDX2-and assess their clinicopathological significance. Methods: A retro-prospective observational study was conducted from April 2023 to October 2024 at G.R. Medical College, Gwalior. Thirty Whipple?s specimens diagnosed with PAC were evaluated. IHC staining for MUC1, CK20, and CDX2 was performed. Tumors were subtyped as INT, PB, or mixed based on marker expression. Data were analyzed using SPSS v26 with p
Keywords: Periampullary carcinoma, Immunohistochemistry, MUC1, CDX2, CK20
How to Cite?: Dr. Shazli Qureshi, Dr. Sudha Iyengar, Dr. Reena Jain, Dr. Ashish Shrivastava, "Sub Classification of Periampullary Carcinoma in Whipple?s Specimen Received Using Immunohistochemistry Markers Mucin1 (MUC1), Cytokeratin 20 (CK20) & Caudal Type Homeodomain Transcription Factor (CDX2) - A Tertiary Care Study", Volume 15 Issue 1, January 2026, International Journal of Science and Research (IJSR), Pages: 1759-1767, https://www.ijsr.net/getabstract.php?paperid=MR26128003755, DOI: https://dx.doi.org/10.21275/MR26128003755