Unveiling Rare but Crucial Neoplasm. The Story of LAMN: A Case Series and Comprehensive Literature Review

Dr. Ajay Sharma, Dr. Anjali Sharma, Dr. Paresh Sharma, Vishvesh Sharma

Abstract: Low-grade mucinous appendiceal neoplasms (LAMN) are rare, histologically distinct tumors of the appendix, often discovered incidentally during imaging or surgery. This study presents a series of five cases of LAMN, highlighting histopathological characteristics, diagnostic challenges, clinical management, and outcomes. We provide an extensive review of literature focusing on its differentiation from appendiceal adenocarcinoma, pseudomyxoma peritonei, and metastatic mucinous adenocarcinomas. Emphasis is laid on the role of immunohistochemistry (IHC) markers, imaging modalities, and treatment options. LAMNs demonstrate an indolent course with a favorable prognosis when managed appropriately, although recurrence and metastasis remain potential risks. This article aims to enhance awareness of LAMN?s unique clinicopathological spectrum, aiding clinicians in accurate diagnosis and optimal management strategies.

Keywords: LAMN, appendecial neoplasm, mucinous tumours, appendix

How to Cite?: Dr. Ajay Sharma, Dr. Anjali Sharma, Dr. Paresh Sharma, Vishvesh Sharma, "Unveiling Rare but Crucial Neoplasm. The Story of LAMN: A Case Series and Comprehensive Literature Review", Volume 14 Issue 8, August 2025, International Journal of Science and Research (IJSR), Pages: 1460-1461, https://www.ijsr.net/getabstract.php?paperid=MR25827111802, DOI: https://dx.doi.org/10.21275/MR25827111802