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Study Papers | General Surgery | India | Volume 14 Issue 3, March 2025 | Popularity: 4.9 / 10
A Prospective Study to Review the Outcome of Ormeloxifene in Fibrocystic Diseases to Reduce Mastalgia and Nodularity
Dr. Neha Ranjan, Dr. Tejaswini Jain, Dr Pankaj Kumar
Abstract: Aim: A prospective study to review the outcome of ormeloxifene in fibrocystic diseases to reduce mastalgia and nodularity. Objectives: 1) To describe fibrocystic diseases of breast.2) To describe the management options available.3) To describe how ormeloxifene is better in medical management. Methods: Patients complaining about breast pain with fibrocystic changes, are treated on an outpatient basis by prescribing ormeloxifene 30 mg twice a week for 3 - 6 months. Inclusion criteria: Female Patients of age group 2nd - 3rd decade, having complaints of cyclic or non cyclic mastalgia with FNAC proven fibrocystic changes. Exclusion Criteria: Female patients age group of more than 40yr.1) Patients having giant fibroadenoma FNAC proven).2) Patients having breast lump with lymphadenopathy.3) Patients not giving consent for ormeloxifene.4) Women who were planning pregnancy in the near future and pregnant women.5) Women with abnormal and undiagnosed uterine bleeding. Results: Total 60 cases were studied. Mastalgia has been improved by 90% in 54 patients within one month of starting ormeloxifene. There is 30% decrease in nodularity after taking drug continuously for 3 months. Conclusion: Ormeloxifene is non steroidal and non hormonal drug having both estrogen agonist and antagonist properties, and approx 47% antineoplastic property. Ormeloxifene has more positive results in reducing mastalgia and nodularity and lesser side effects than other modalities (danzole tamoxifen).
Keywords: fibrocystic diseases, mastalgia Treatments, ormeloxifene, breast nodule, non hormonal management
Edition: Volume 14 Issue 3, March 2025
Pages: 439 - 442
DOI: https://www.doi.org/10.21275/MR25309155349
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