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Analysis Study Research Paper | Dentistry | Netherlands | Volume 14 Issue 3, March 2025 | Popularity: 5.3 / 10
Periodontal Health Decline in Diabetic Patients: Clinical Reports, Cytokine Analysis, and Antidiabetic Therapies
Sabri Fatih Kursunlu
Abstract: Diabetes mellitus induces chronic hyperglycemia and systemic inflammation, leading to periodontal deterioration characterized by gingival inflammation, bone loss, and deep periodontal pockets. This review explores the pathophysiological mechanisms linking diabetes and periodontal disease, focusing on inflammatory cytokines (TNF-α, IL-1β, and IL-6) and their role in disease progression. Five clinical case reports illustrate how different antidiabetic medications metformin, insulin, DPP-4 inhibitors, GLP-1 receptor agonists, and SGLT2 inhibitors affect periodontal healing. Special attention is given to Rybelsus, a novel oral GLP-1 receptor agonist, in comparison with other treatments. Findings highlight the necessity of multidisciplinary treatment strategies and strict glycemic control for improving periodontal health in diabetic patients.
Keywords: Diabetes, Periodontal Health, Inflammation, Cytokines, Rybelsus, Antidiabetic Therapy
Edition: Volume 14 Issue 3, March 2025
Pages: 263 - 265
DOI: https://www.doi.org/10.21275/MR25305205201
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