Solid Dispersion: A Novel Technique to Enhancement of Solubility

Kulkarni Bhavna Dilipbhai, Dr. Chainesh N. Shah, Dr. Umesh Upadhyay

Abstract: Solid dispersion was proposed as an effective method to improve the dissolution rate and bioavailability of various hydrophobic drugs. This article reviews solid dispersion preparation techniques and summarizes some recent technological advances. Different types of solid dispersions are characterized by molecular arrangement. Some of the opsserational aspects to consider when preparing solid dispersions, such as carrier selection and physicochemical characterization techniques, are also discussed, along with insights into the molecular structure of drugs in solid dispersion. Finally, a deeper reason for the low commercialization of solid waste and new recycling is considered.

Keywords: Solid dispersion, transport, solubility, elimination, bio-availability