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Case Studies | Hematology | India | Volume 13 Issue 2, February 2024

Waldenstroms Macroglobulinemia with Amyloid Cardiomyopathy - A Case Report

Dr. Mohammed Shanil P | Dr. Farsana Jasmin K

Abstract: Waldenstroms macroglobulinemia is a malignant disease of B cells that secrete IgM paraprotein similar to multiple myeloma and non - hodgkins lymphoma. WM cells have features of both plasma cells and lymphocytes and are called lymphoplasmocytoid. Secretion of the IgM paraprotein leads to hyperviscosity and vascular complications and is associated with MYD88 mutation. This extremely rare neoplasm has an annual incidence of 4 cases per million people contributing approximately 2% of all hematologic malignancies. The diagnosis is usually challenging due to a lack of specific morphologic, immunophenotypic or chromosomal changes.

Keywords: Waldenstroms macroglobulinemia, IgM paraprotein, hyperviscosity, MYD88 mutation, hematologic malignancies

Edition: Volume 13 Issue 2, February 2024,

Pages: 1654 - 1655