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Research Paper | Chemistry | India | Volume 12 Issue 7, July 2023
Unique & Novel Spectrophotometric Determination of Linagliptin Drug in Bulk and Pharmaceutical Formulations by using Iron & 1, 10 Phenthroline
Vaishali Parastekar | Makhijani Ritika M
Abstract: For the determination of Linagliptin in pure and dosage forms, a new easy, sensitive, precise and consistent Spectrophotometric method has been developed. This method is based on the principle of developing a orange colour chromogen by oxidation of drug with 1,10-phenanthroline, which is measured at 510nm. The developed method obeyed the Beer?s Lambert?s Law in the concentration range of 0.0-10 ?g/cm3. For the developed method the molar absorptivity is 1.4176 X 10 4 Lmol-1cm-1 and sandell?s sensitivity are found to be 0.0333 ?g/cm2. Optimization of different experimental parameters, affecting the colour development and stability of coloured products are carefully studied. This method is victoriously applied to pharmaceutical formulations. Results obtained from the developed method are in good accordance with those of the other proposed method.
Keywords: Linagliptin, Spectrophotometric method and 1, 10-Phenanthroline
Edition: Volume 12 Issue 7, July 2023,
Pages: 1647 - 1651