A Comparative Study between Treatment of Rickets with Stoss Therapy and Daily Dose of Vitamin D3 Therapy

Dr. Om Prakash Kumar, Dr. Pravin Kumar Sahoo, Dr. Nihal, Dr. Madan Kr Sharma, Dr. Vivek Raj, Dr Abhishek Kumar

Abstract: Objectives: This study aims to compare the efficacy and side effects of stoss therapy and daily dosing with vitamin D3 in the treatment of rickets. Participants: The study included 30 children aged 6 months to 5 years with clinically and radiologically confirmed rickets. Materials and methods: Group 1 n=15 received a single oral dose of 300, 000 IU of vitamin D3, while Group 2 n=15 received a daily oral dose of 4000 IU of vitamin D3 for 10 weeks. Radiological healing was assessed after 12 weeks, and serum 25 - hydroxyvitamin D levels were compared at baseline and after 12 weeks. Results: Serum 25 - OH vitamin D levels significantly increased from baseline to 12 weeks in both groups. However, stoss therapy resulted in a significantly greater increase in vitamin D levels compared to daily dosing. Two children in Group 1 developed hypercalcemia at 12 weeks, but no cases of hypervitaminosis D were observed. Conclusion: Radiological and biochemical parameters did not differ significantly between the two treatment groups. However, patients treated with stoss therapy had higher vitamin D3 levels.

Keywords: rickets, stoss therapy, daily dosing therapy of rickets, vitamin D deficiency, genu valgus, genu varus, windswept deformity, hypovitaminosis, treatment outcomes