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Comparative Studies | Orthopaedic Surgery | India | Volume 12 Issue 8, August 2023
A Comparative Study between Treatment of Rickets with Stoss Therapy and Daily Dose of Vitamin D3 Therapy
Abstract: Objectives: This study aims to compare the efficacy and side effects of stoss therapy and daily dosing with vitamin D3 in the treatment of rickets. Participants: The study included 30 children aged 6 months to 5 years with clinically and radiologically confirmed rickets. Materials and methods: Group 1 n=15 received a single oral dose of 300, 000 IU of vitamin D3, while Group 2 n=15 received a daily oral dose of 4000 IU of vitamin D3 for 10 weeks. Radiological healing was assessed after 12 weeks, and serum 25 - hydroxyvitamin D levels were compared at baseline and after 12 weeks. Results: Serum 25 - OH vitamin D levels significantly increased from baseline to 12 weeks in both groups. However, stoss therapy resulted in a significantly greater increase in vitamin D levels compared to daily dosing. Two children in Group 1 developed hypercalcemia at 12 weeks, but no cases of hypervitaminosis D were observed. Conclusion: Radiological and biochemical parameters did not differ significantly between the two treatment groups. However, patients treated with stoss therapy had higher vitamin D3 levels.
Keywords: rickets, stoss therapy, daily dosing therapy of rickets, vitamin D deficiency, genu valgus, genu varus, windswept deformity, hypovitaminosis, treatment outcomes
Edition: Volume 12 Issue 8, August 2023,
Pages: 86 - 92