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Research Paper | Oncology Science | Volume 12 Issue 2, February 2023 | Pages: 1065 - 1067 | India
Successful High-Titer Immunoglobulin Therapy for Persistent Parvovirus B19 Infection in a Lymphoma Patient Treated with Rituximab-Combined Chemotherapy
Abstract: Persistent parvovirus B19 infection is likely to develop in the absence of appropriate immune responses. Because this virus has a tropism for human erythroid progenitor cells and induces apoptosis in the infected cells, persistent infection causes pure red cell aplasia (PRCA) [1?3]. Rituximab is a chimeric monoclonal antibody against B-cell antigen (CD20) and currently is used to treat several B-cell lymphoproliferative diseases. Although chemotherapy combined with rituximab results in excellent treatment of B-cell lymphoproliferative disease, this strategy seems to reduce humoral and cellular immunity [5]. Recent reports showed that persistent parvovirus B19 infection may occur after antibody-combined chemotherapy against lymphoma [6?8].
Keywords: Rituximab, Chemotherapy, High-Titer Immunoglobulin Therapy
How to Cite?: Diksha Gimekar, Meenakshi Bhattacharya, "Successful High-Titer Immunoglobulin Therapy for Persistent Parvovirus B19 Infection in a Lymphoma Patient Treated with Rituximab-Combined Chemotherapy", Volume 12 Issue 2, February 2023, International Journal of Science and Research (IJSR), Pages: 1065-1067, https://www.ijsr.net/getabstract.php?paperid=MR23215174307, DOI: https://dx.doi.org/10.21275/MR23215174307