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Masters Thesis | Pediatrics | India | Volume 12 Issue 1, January 2023

Study on Clinical Profile and Efficacy of Prazosin in Scorpion Sting Envenomation in Children of Anathapur

Aswathy Thankachy .K | Dr. S. Srilatha | Dr. Shankar Narayana

Abstract: This study was an evaluation of the pattern of presentation, the outcome and the ef?cacy of Prazosin in scorpion sting envenomation at a tertiary care hospital in Anathapur, Andhra Pradesh. Methods: A total of 120 consecutive children were prospectively studied. The data included demographics, the time of presentation to the hospital, the clinical features, and the premedication which was given before the arrival of the subjects at the hospital, response to the oral Prazosin and the hospital outcome. Results: Local pain, sweating and peripheral circulatory failure were the common clinical presentations. Complications like acute pulmonary oedema, myocarditis, shock and encephalopathy were also seen. These were treated with a combination of Prazosin with either inotropes or vasodilators. Mortality was seen in 6 (5%) children. The usage of antihistaminics and steroids in these children led to higher mortality. Oral Prazosin, a postsynaptic alpha -1 blocker, is a highly effective drug for scorpion sting envenomation. Conclusion: Scorpion sting envenomation is an acute life threatening emergency and an early presentation to the hospital and an early intervention with Prazosin can hasten the recovery in the scorpion sting victim.

Keywords: scorpion sting, envenomation, myocarditis, oral prazosin. vasodilators, late presentation, PICU

Edition: Volume 12 Issue 1, January 2023,

Pages: 1213 - 1216