International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064




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Review Papers | Life Sciences | India | Volume 12 Issue 10, October 2023 | Rating: 5 / 10


Investigation on Protective Action of Phyllanthus amarus & Sidaacuta Extracts due to Anticancer Drug Doxorubicin Induced Toxicity Using Chick Embryo Model: A Comprehensive Review

Abhiruchi Sable | Dr. Renu Shrivastava | Rajendra Chauhan [2]


Abstract: Cancer remains a significant global health challenge, with chemotherapy being a prominent treatment modality. However, the efficacy of chemotherapeutic agents, such as Doxorubicin, often comes at the cost of adverse side effects and toxicities. In recent years, there has been growing interest in natural compounds as potential protective agents against chemotherapy-induced toxicity. This comprehensive review paper focuses on investigating the protective action of extracts from Phyllanthus amarus and sidaacuta against Doxorubicin-induced toxicity, utilizing the chick embryo model as a unique experimental system. This review provides a thorough examination of the existing literature, offering insights into the mechanisms underlying Doxorubicin-induced toxicity, the phytochemical composition and traditional uses of Phyllanthus amarus and sidaacuta, and the suitability of the chick embryo model for studying drug-induced toxicity. Through an extensive analysis of relevant studies, we present compelling evidence for the protective effects of Phyllanthus amarus and sidaacuta extracts against Doxorubicin-induced toxicity. In conclusion, this review underscores the promising potential of Phyllanthus amarus and sidaacuta extracts as protective agents against Doxorubicin-induced toxicity and highlights the relevance of the chick embryo model in preclinical research. Further exploration of these natural compounds may hold the key to enhancing the safety and efficacy of chemotherapy in cancer treatment.


Keywords: Cancer, Chemotherapy, toxicity, phytochemicals, Phyllanthus amarus, sidaacuta


Edition: Volume 12 Issue 10, October 2023,


Pages: 1744 - 1751



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