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Case Studies | Medicine | India | Volume 12 Issue 10, October 2023

A Rare Case of Systemic Lupus Erythematosus with Autoimmune Hepatitis Leading to Hepatic Cirrhosis

Debashree Karmakar | Rima Moni Doley

Abstract: Systemic Lupus Erythematosus SLE and Autoimmune Hepatitis AIH are complex autoimmune disorders that, when coexisting, pose significant diagnostic and therapeutic challenges. This article explores a case of a 38-year-old female with a history of SLE and hypothyroidism who presented with abdominal pain and breathing difficulties. Extensive clinical, serological, and radiological investigations revealed the coexistence of SLE and cirrhosis of the liver with esophageal varices, likely as a consequence of AIH. This case highlights the importance of distinguishing between SLE-associated hepatitis Lupoid hepatitis and AIH associated with SLE, as their disease courses differ. The article underscores the limitations of biochemical parameters in differentiation and emphasizes the diagnostic value of liver biopsy.

Keywords: Systemic Lupus Erythematosus, Autoimmune Hepatitis, Coexistence, Diagnosis, Liver Biopsy

Edition: Volume 12 Issue 10, October 2023,

Pages: 685 - 686