International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Comparative Studies | Medical Surgical | India | Volume 11 Issue 12, December 2022


Comparison between Intrathecal Bupivacaine and Bupivacaine with Two Different Doses of Clonidine in Lower Limb and Lower Abdominal Surgeries

Prabhu B G | Sindhu G B


Abstract: Clonidine, a centrally acting ?2 adrenergic agonist has been under use as an adjuvant with hyperbaric bupivacaine for prolonging analgesia and maintaining hemodynamic stability during lower limb orthopedic and lower abdominal surgeries. This study is designed to compare the clinical effects of addition of two different doses of clonidine in the patients undergoing lower limb and lower abdominal surgeries. Materials and Methods: Our study consisted of 78 patients aged between 18-60 years of either sex, ASA physical status I and II undergoing elective lower limb surgeries were randomly selected for the study and were divided into three groups of 26 each. Group B-Received 0.5% hyperbaric Bupivacaine 15 mg intrathecally. Group C1-Received 0.5% intrathecal hyperbaric Bupivacaine 15 mg + Clonidine 15 mcg Group C2-Received 0.5% intrathecal hyperbaric Bupivacaine 15mg + Clonidine 30 mcg. Results: Administration of intrathecal clonidine to 0.5% hyperbaric Bupivacaine significantly prolonged duration of motor blockade. Total duration of analgesia was compared between three groups. Group C2 had longer duration of analgesia time with 285?17.40 minutes. Conclusion: Intrathecal addition of clonidine significantly prolongs the duration of motor block providing good postoperative analgesia as well as improved quality of block.


Keywords: Intrathecal Bupivacaine, Clonidine, Sensory and Motor blockade


Edition: Volume 11 Issue 12, December 2022,


Pages: 221 - 227


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