A Review Article on Self - Micro Emulsifying Mouth Dissolving Film

Pepakayala Praveena, K. Anne Vijetha

Abstract: Article aims to formulate a self micro emulsifying mouth dissolving film (SMMDF) is a novel dosage form, an integration of the self microemulsifying drug delivery system (SMEDDS) in SMMDF. Preformulated SMEDDS increases the solubility of class - 2 and class 4 drugs biopharmaceutical classification and these SMEDDS incorporated into mouth dissolving film that are targeted for diseases like angina pectoris, congestive heart failure, Asthma, Parkinson's convulsions, Anti histamine etc, by enhancing absorption rate through oral absorption, avoid first pass metabolism, and show rapid/quick onset of action. SMEDDS are the isotrotic mixtures of oil, surfactant, co - surfactants upon mild agitation followed by dilution with aqueous medium (gastro - intestinal fluids) this system can form oil - in - water (o/w) micro emulsion having small globular size they can provide large surface area for absorption and improve oral bioavailability of drug. SMEDDS are liquid, that improve the solubility of poorly water soluble drugs in aqueous medium having stability problems of liquid. To stabilize the liquid SMEDDS are incorporated into complex polymeric matrices oral fast dissolving films that can be disintegrate / dissolve in the mouth within 5 minutes.

Keywords: Integration, mouthfilm, preformulated, polymeric matrices, self microemulsifying drug delivery