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Review Papers | Pharmaceutical Science | India | Volume 10 Issue 12, December 2021

Elucidation the Synthesis of an Antibiotic Medicine Chloramphenicol Palmitate with its Stepwise Mechanism

Rahul Thakur

Abstract: Chloramphenicol is an antibiotic or antibacterial medicine that was the first manmade drug. Chloramphenicol is a crystalline white or yellowish - white powder and is also available in fine crystal form. It is used for various bacterial infections. An eye ointment of Chloramphenicol is used to treat conjunctivitis or pink eyes, Plague, Typhoid, Meningitis, Cholera, septicaemia etc are also treated by Chloramphenicol medicine or by its injection. Chloramphenicol is bitter in taste if we take via orally. To remove its bitterness Chloramphenicol is treated with Palmitic acid via esterification and it becomes Chloramphenicol Palmitate. Hence it becomes tasteless and water - insoluble. In this review, I present the synthesis of Chloramphenicol Palmitate with its simple and clearly understandable mechanism which is very useful to everyone to understand that how Chloramphenicol Palmitate is synthesized. I also present the explanation of its all steps with its explained mechanism.

Keywords: Palmitic Acid, Chloramphenicol palmitate, Antibiotic Chloramphenicol

Edition: Volume 10 Issue 12, December 2021,

Pages: 365 - 376