A Review on Leukocyte Adhesion Deficiency

Rasika Bhitale, Chetan Masram, Arshad Mulani, Yukta Nagda, Priti Ranyewale, Nimisha Gaikwad, Shreya Dhepe, Harsh Pawar

Abstract: Leukocyte Adhesion Deficiency (LAD) is a group of rare autosomal recessive (<1 in 1000000 births) inherited disorders belonging to an immune deficiency and peripheral neutrophilia. Naturally, in the human body, a series of several definite steps results in the movement of leucocytes from the bloodstream to the site of infection, which also involves some adhesion of leucocytes to the foreign molecules/antigens due to mutations in CD18 glycoprotein. A failure in adhesion of leukocytes to vascular endothelium affecting their movement to extravascular space gives rise to a group of rare immunodeficiency known as Leukocyte Adhesion Deficiency. The paper aims to review the available relevant literature and overall study LAD and present a concise quality overview and analysis of the same.

Keywords: Immunodeficiency, Integrin, Stem cell transplant, CD18, Neutrophilia

How to Cite?: Rasika Bhitale, Chetan Masram, Arshad Mulani, Yukta Nagda, Priti Ranyewale, Nimisha Gaikwad, Shreya Dhepe, Harsh Pawar, "A Review on Leukocyte Adhesion Deficiency", Volume 10 Issue 11, November 2021, International Journal of Science and Research (IJSR), Pages: 304-308, https://www.ijsr.net/getabstract.php?paperid=MR211029221816, DOI: https://dx.doi.org/10.21275/MR211029221816