A Review on Leukocyte Adhesion Deficiency

Rasika Bhitale, Chetan Masram, Arshad Mulani, Yukta Nagda, Priti Ranyewale, Nimisha Gaikwad, Shreya Dhepe, Harsh Pawar

Abstract: Leukocyte Adhesion Deficiency (LAD) is a group of rare autosomal recessive (<1 in 1000000 births) inherited disorders belonging to an immune deficiency and peripheral neutrophilia. Naturally, in the human body, a series of several definite steps results in the movement of leucocytes from the bloodstream to the site of infection, which also involves some adhesion of leucocytes to the foreign molecules/antigens due to mutations in CD18 glycoprotein. A failure in adhesion of leukocytes to vascular endothelium affecting their movement to extravascular space gives rise to a group of rare immunodeficiency known as Leukocyte Adhesion Deficiency. The paper aims to review the available relevant literature and overall study LAD and present a concise quality overview and analysis of the same.

Keywords: Immunodeficiency, Integrin, Stem cell transplant, CD18, Neutrophilia