International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 11 | Views: 103

Review Papers | Biotechnology | India | Volume 10 Issue 11, November 2021


A Review on Leukocyte Adhesion Deficiency

Rasika Bhitale | Chetan Masram | Arshad Mulani | Yukta Nagda | Priti Ranyewale | Nimisha Gaikwad | Shreya Dhepe | Harsh Pawar


Abstract: Leukocyte Adhesion Deficiency (LAD) is a group of rare autosomal recessive (<1 in 1000000 births) inherited disorders belonging to an immune deficiency and peripheral neutrophilia. Naturally, in the human body, a series of several definite steps results in the movement of leucocytes from the bloodstream to the site of infection, which also involves some adhesion of leucocytes to the foreign molecules/antigens due to mutations in CD18 glycoprotein. A failure in adhesion of leukocytes to vascular endothelium affecting their movement to extravascular space gives rise to a group of rare immunodeficiency known as Leukocyte Adhesion Deficiency. The paper aims to review the available relevant literature and overall study LAD and present a concise quality overview and analysis of the same.


Keywords: Immunodeficiency, Integrin, Stem cell transplant, CD18, Neutrophilia


Edition: Volume 10 Issue 11, November 2021,


Pages: 304 - 308


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