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Research Paper | Chemistry | India | Volume 7 Issue 11, November 2018
Synthesis of 5-Ketothiazoles
Abstract: Many indole derivatives are bioactive and several are useful clinically prescribed drugs, thus indole nucleus has long been recognised as a good pharmacophore. The bioactive amine tryptamine and the amino acid tryptophan contain indole nucleus. Not only natural but synthetic indole derivatives also show excellent biological activities. As part of our interest in marine alkaloids and also on aminothiazoles, we observed that the reported synthesis of dendrodoine will be useful only to prepare 3-N, N-dialkylamino derivatives alone, since mono or unsubstituted ureas would react with Cl-CO-S-Cl differently, unlike disubstituted ureas. There exists no direct cyclisation route to such acylthiadiazolylamines. Hence the preparation of dendrodoine analogs having variety of substitients is deemed to be not easy. However, the substitution of a 2-aminothiazole unit in place of the amino-1, 2, 4-thiadiazole unit in dendrodoine appeared attractive.
Keywords: Ketothiazoles, dendrodoine, amino acid, tryptophan
Edition: Volume 7 Issue 11, November 2018,
Pages: 1975 - 1977